Flying saucer sign oct plaquenil

Discussion in 'Buy Chloroquine Online' started by apirat, 22-Feb-2020.

  1. glebovgin XenForo Moderator

    Flying saucer sign oct plaquenil


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    All three demonstrated characteristic perifoveal outer retinal abnormalities seen on SD OCT that we have termed the “flying saucersign; these findings include preservation of the outer retinal structures in the central fovea, perifoveal loss of the photoreceptor IS/OS junction and outer retinal thinning, posterior or “sinkhole” displacement of the inner retinal structures toward the retinal pigment epithelium, 25 and variable loss of the normal foveal depression. Plaquenil maculopathy is an uncommon side effect of the systemic medication, Hydroxychrloroquine. This lecture will guide the optometrist in diagnosis and management of Plaquenil maculopathy. The course will review updated guidelines from the American Academy of Ophthalmology and discuss exciting new research utilizing OCT. Three patients with early HCQ toxicity and HVF 10-2 perifoveal defects were found to have loss of the perifoveal photoreceptor inner segment/outer segment IS/OS junction with intact outer retina directly under the fovea, creating the “flying saucersign.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Flying saucer sign oct plaquenil

    Spectral domain optical coherence tomography as an effective., Pacific University College of Optometry

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  3. In SD-OCT, the so-called “flying saucer sign” can be seen in these patients. This sign is caused by the loss of the perifoveal ellipsoid line, perifoveal thinning of the external nuclear layer and an apparent posterior displacement of the external retina structures towards the pigment epithelium, combined with the preservation of the ellipsoid line in the foveal region, producing said flying saucer sign. 5, 6

    • Signs of hydroxychloroquine toxicity in a patient with..
    • Spectral domain optical coherence tomography as an effective screening..
    • SD-OCT As screening test for hydroxychloroquine..

    Specifically, SD-OCT can detect loss of the perifoveal photoreceptor inner segment/outer segments line PIL  At the macula, an ovoid appearance can appear described as “flying saucersign by Chen, et al 18 Repeat 10-2 HVF testing demonstrated the dense paracentral scotomas. SD-OCT showed loss of the parafoveal inner/outer segment junction, thinning of the parafoveal outer nuclear layer, and a loss of the normal foveal depression, which is characteristic for hydroxychloroquine retinal toxicity Figure 3. SD-OCT enables the detection of early loss in external layers and lines, remaining intact below the fovea the flying saucer sign. In 10% of HCQ early toxicity cases, the most specific and objective test SD-OCT could yield false negatives, and for this reason it is important to combine this test with visual field.

     
  4. Kolbasa05 Well-Known Member

    Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine - Side Effects, Dosage, Interactions. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Plaquenil Hydroxychloroquine Side effects, Images, Uses.
     
  5. koder321 New Member

    Hydroxychloroquine - Wikipedia Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine -sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda.

    PLAQUENIL Pediatric Drug Monograph ScriptSave WellRx
     
  6. klimko XenForo Moderator

    Plaquenil and sun exposure - Sjogren's World Hi All, I've been on plaquenil for a couple of months now and it is definitely affecting my tolerance to the sun. I burn more easily which I didn't think was possible since I am extremely fair and already have to be very sun smart and am starting to get rashes after sun exposure.

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