To characterize structural changes of HCQ retinopathy with SD-OCT after drug cessation. Setting: Private practice and academic institution. Patient Population: Patients at New England Eye Center and Ophthalmic Consultants of Boston in Boston, MA diagnosed with HCQ retinopathy and followed after drug cessation. Malaria chemoprophylaxis chloroquine phosphate tablet 500 mg Hydroxychloroquine retina Hydroxychloroquine retinal toxicity screening Chloroquine oral pigmentation Oct 01, 2018 C 18 H 26 ClN 3.2H 3 PO 4 Molecular Weight 515.87 Each tablet contains 500 mg of Chloroquine phosphate USP, equivalent to 300 mg Chloroquine base. Inactive Ingredients colloidal silicon dioxide, dibasic calcium phosphate, hydroxypropylmethylcellulose, magnesium stearate. Pasadhika and Fishman evaluated the peripapillary retinal nerve fiber layer RNFL thickness and macular inner and outer retinal thickness using spectral domain optical coherence tomography SD-OCT in patients with long-term exposure to hydroxychloroquine or chloroquine. In obvious toxicity, the nasal inner subfield showed more thinning than the temporal inner subfield at 12 months after drug cessation p = 0.018, 95 % CI −1 to −8 μm. Conclusions Once HCQ retinopathy is diagnosed and the medication is discontinued, structural retinal changes commonly occur. Main Outcome Measures: SD-OCT findings suggestive of HCQ retinopathy before parafoveal ellipsoid disruption. Retrospective clinical data review by the Boston Image Reading Center. Chloroquine toxicity oct Hydroxychloroquine toxicity - EyeWiki, Chloroquine and Hydroxychloroquine Toxicity Workup Approach. Plaquenil weightHow to stop taking plaquenil Apr 30, 2013 Plaquenil Toxicity Condition/keywords plaquenil toxicity, hydroxychloroquine toxicity Imaging device Optical coherence tomography system Description SD-OCT scan from a 44-year-old woman with bilateral plaquenil toxicity. There is damage visible in the outer retina in a perifoveal distribution. Related files Plaquenil Toxicity - Retina Image Bank. Expanded spectral domain-OCT findings in the early detection.. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as, age of greater than 60 years, daily dose more than 6.5 mg/kg; use of the drug more than 5 years, obesity, preexisting retinal disease and, renal or liver failure. Chloroquine CQ is used to prevent and treat malaria and amebiasis,1 while hydroxychloroquine HCQ, a less toxic metabolite of chloroquine, is used to treat rheumatic diseases such as systemic lupus erythematosus SLE, rheumatoid arthritis RA, juvenile idiopathic arthritis JIA and Sjogren's syndrome.2 We herein report the optical coherence tomography OCT findings in a case of chloroquine-induced macular toxicity, which to our knowledge, has so far not been reported. A 53- year-old lady on chloroquine for treatment of rheumatoid arthritis developed.