All my issues were resolved over a years time on low doses. I believe my problems started with side effects of a statin, which I stopped taking during my Plaquenil treatment but resumed after symptoms were resolved. Prilosec and plaquenil interactions Side effects from plaquenil on eye Chloroquine cholera Chloroquine p62 I am a very young 62 year old who just started taking Plaquenil for Undifferentiated Connective Tissue Disease which is known to advance to Lupus. Plaquenil may just prevent this. Also, I view taking it as a “one-day-at a time event”, and not a “for the rest of my life” event. I started plaquenil in April I was diagnosed UCTD at that time but have mildly positive lupus test, RNP, and scl-70. I was having morning stiffness and swelling in my hands, hot rashes on my neck, and joint pain in only one finger. Plaquenil takes quite a long time to get to its peak effectiveness depending on what you read, anywhere from 3 months to a year. Unless you are having significant side effects, try to give it at least 6 months before you decide it doesn't work for you. Has anyone had neurological issues resolved with a Plaquenil treatment? I used Plaquenil years ago for extreme muscle and joint issues and it seemed to work fine. Years later I am now having small fiber issues in my hands which I think were triggered by side effect of statins and am looking for solutions. Plaquenil lupus forum What About Plaquenil? Lupus Forum Conditions and Diseases, Plaquenil - @Cookiiez95 - Lupus - 20140827 - Inspire Plaquenil stomach ulcerCan hydroxychloroquine be crushedPlaquenil and acetaminophen Lupus Forums at The Lupus Site Home Forums As you can see we have transferred to new forum software which is much more stable and will eliminate problems that we had with the old software. Lupus Forums at The Lupus Site. PLAQUENIL" Rheumatoid Arthritis Community - Support Group. Hydroxychloroquine plaquenil ProHealth Fibromyalgia, ME.. Patient Forums for Lupus. Part of the Bones, joints and muscles category. Symptom, treatment and advice from community members Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Specifically, anti-malarial medications have shown to improve muscle and. Plaquenil is effective for Lupus patients, as well as people with UCTD described to me by a rheumatologist as "Lupus-like" or "Lupus-lite" or "mild Lupus". So it's very possible to be on Plaquenil without having a formal Lupus diagnosis.