Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Mechanism of action of chloroquine in malaria Plaquenil depressed Plaquenil and sulfasalazine combination Yes it increased depression and I was getting majorly confused on it. I was on it for about 5 years. The confusion and feeling " detached" caused me to discuss it with my therapist who looked up side effects of all my meds. She thought it was the plaquenil and it was. Plaquenil and Depression - a real-world study. Summary Depression is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Enbrel, and have Pain. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil and depression Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis, Will you have Depression with Plaquenil - eHealthMe Hydroxychloroquine and dry mouthMeloxicam and plaquenilChloroquine vs doxycyclineSigns of plaquenil toxicity Depression can be a common manifestation in people with lupus. It is often difficult to determine whether the depression is an integral part of lupus as it is in some patients, where management of the lupus itself often lifts the depression, whether the depression has arisen in response to having a chronic painful illness. Lupus and Depression - LUPUS UK. Plaquenil vs. Prednisone Prescription Treatment for.. Lupus and depression Know the signs and how to get help.. Major Depression is #139 concern in Plaquenil discussions. Plaquenil is an arthritis medication and an anti infectious agent. Uses Plaquenil is prescribed for Lupus, RA, Sjogren's Syndrome and Joint Pain and is mostly mentioned together with these indications. Plaquenil Hydroxychloroquine belongs to a group of medications known as anti-inflammatories and antimalarials. It is used alone or in combination with other anti-arthritic medications to treat rheumatoid arthritis. It helps to reduce pain, stiffness, and swelling in joints. If you Google 'Plaquenil Depression' you will see that it has this effects on others. That's how I got to this post! Hopefully there is something else I can try to deal with my symptoms. Also, about Cymbalta.helped me for a while with depression and fibro or whatever this is I have, HOWEVER, I went into a deep depression even while taking it.