It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Does plaquenil cause scalp itch and sweating Hydroxychloroquine nutrient interactions Chloroquine phosphate in myocardial infarction Chloroquine phosphate how long do side effects last Aug 14, 2017 Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria 2. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. Hydroxychloroquine and sulfasalazine are used. Though DMARDs can have side effects, there is a good reason to take them -- they're proven to work against rheumatoid arthritis. Even if you are. Rated Hydroxychloroquine for Rheumatoid Arthritis Report Plaquenil was a miracle drug for me. It began to work in 3 weeks and within 6 months my inflammation had gone from over 40 to 5.5. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. Plaquenil works rheumatoid arthritis Taking Plaquenil for Rheumatoid Arthritis, DMARDs for Treating Rheumatoid Arthritis Starting plaquenilHydroxychloroquine chemotherapy What next if plaquenil doesn't work? Support Forums Rheumatoid Arthritis New Topic Reply. for me methotreaxte and plaquenil does't work and i' intonate of sulfa so i am started embrel which states you have to have tried 2 of 3 meds and methotrexate is 1 of them. good luck What next if plaquenil doesn't work?. Hydroxychloroquine Reviews Everyday Health. Hydroxychloroquine Side Effects, Dosage, Uses, and More. How to use Plaquenil. Lupus and/or rheumatoid arthritis patients will most likely take this medication by mouth, usually once or twice daily or as directed. Hydroxychloroquine generally is given to adults in doses of 200 mg or 400 mg per day. In some cases, higher doses can be used. Plaquenil reduces inflammation in many Rheumatic disorders, the mode of action is pretty complicated though so I shan't bore you with all the details, but basically it prevents your dendritic cells these are messengers for your immune system, if you will from interacting with your T-Cells a special type of white blood cell which through a convoluted and boring process, causes inflammation. Plaquenil hydroxychloroquine "When first diagnosed with rheumatoid arthritis RA plaquinel worked after a couple weeks. I was in remission soI stopped but Dr upset as he said it was important to keep damage to joints down.