I would appreciate feedback on the reasoning outlined below. I have convinced myself that it makes sense, but am looking for independent feedback and have been struggling to get it. Plaquenil info Can plaquenil cause gingivitis in humans Chloroquine/hydroxychloroquine is extruded to the extracellular medium mostly by exocytosis and/or through the action of the multidrug resistance protein MRP-1, a cell surface drug transporter belonging to the ATP-binding cassette family, which also includes the more thoroughly studied P-glycoprotein. Methotrexate Moderate Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral. Mechanism of action of antimalarial drugs inhibition of antigen processing and presentation. Lupus 1993; 2 Suppl 1S9. Fox R. Anti-malarial drugs possible mechanisms of action in autoimmune disease and prospects for drug development. , etc.), or provide argument why this is a dumb idea. I would greatly appreciate it if someone could knit-pick this with a fine tooth comb and try and find some mistake I've made (off by a order of magnitude? Mechanism of action hydroxychloroquine Hydroxychloroquine inhibits proinflammatory signalling., Plaquenil hydroxychloroquine sulfate dose, indications. Plaquenil ocular side effects10-2 plaquenilAnkylosing spondylitis hydroxychloroquineWill plaquenil help cancerPlaquenil para el lupus Mechanism of Action of Hydroxychloroquine as an Antirheumatic Drug By Robert I. Fox The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus. These compounds lead to improvement of clinical and laboratory parameters. Mechanism of action of hydroxychloroquine as an antirheumatic.. REFERENCES - UpToDate. Chloroquine analogues in drug discovery new directions of.. In addition, the biological effect of hydroxychloroquine was demonstrated by a decrease in levels of serum IgG and IgM, and in erythrocyte sedimentation rate, as was reported in previous trials of hydroxychloroquine in primary Sjögren syndrome. 11-14 Such a decrease might result from the different mechanisms of action of hydroxychloroquine. A study of about 200 patients with a history of hydroxychloroquine retinopathy, including 36 Asian patients, found that the pericentral pattern occurred in half the Asian patients but only 2% of the white patients. 31 The mechanism for this finding is unclear, but because pericentral retinopathy spares the macula, it can be missed using standard screening methods. Mechanism of action. Hydroxychloroquine increases lysosomal pH in antigen-presenting cells. In inflammatory conditions, it blocks toll-like receptors on plasmacytoid dendritic cells PDCs. citation needed Hydroxychloroquine, by decreasing TLR signaling, reduces the activation of dendritic cells and the inflammatory process.