The fever is usually above 39 °C (102 °F) and sometimes reaching 40 °C (104 °F) and may be biphasic—lasting several days, breaking, and then returning. Fever occurs with the onset of viremia, and the level of virus in the blood correlates with the intensity of symptoms in the acute phase. Chloroquine mechanism of action animation Hydroxychloroquine should you take if you are anemic Plaquenil liver toxicity Plaquenil hives treatment Due to the alkalisation of endosomes, chloroquine was an effective in vitro treatment against Chikungunya virus when added to Vero cells prior to virus exposure. The mechanism of inhibition likely involved the prevention of endocytosis and/or rapid elevation of the endosomal pH and abrogation of virus–endosome fusion. Aug 22, 2016 The viral capping enzyme nsP1 a novel target for the inhibition of chikungunya virus infection. De Lamballerie, X. et al. On chikungunya acute infection and chloroquine treatment. Sep 15, 2009 Treatment for chikungunya fever is limited to supportive care rest, fluids, antipyretics, and analgesics. Although there have been in vitro studies and limited clinical data suggesting a role for certain drugs, such as chloroquine, acyclovir, ribavirin, interferon-α, and corticosteroids. However, headache, insomnia and an extreme degree of exhaustion remain, usually about five to seven days. When Ig M, an antibody that is a response to the initial exposure to an antigen, appears in the blood, viremia begins to diminish. On chikungunya acute infection and chloroquine treatment Chikungunya Disease and Chloroquine Treatment, The viral capping enzyme nsP1 a novel target for the. Plaquenil mechanism of action in lupusUsp grade chloroquine Currently, no specific treatment for chikungunya is available. Supportive care is recommended, and symptomatic treatment of fever and joint swelling includes the use of nonsteroidal anti-inflammatory drugs such as naproxen, non-aspirin analgesics such as paracetamol acetaminophen and fluids. Chikungunya - Wikipedia. Chikungunya Fever An Epidemiological Review of a Re-Emerging.. Chikungunya virus infection - Emerging treatments BMJ Best.. Chikungunya virus infection may resemble other illnesses such as dengue fever, Zika virus, malaria, mononucleosis, strep, and others, and it is important to rule out other causes for symptoms and signs. There is no specific medical treatment for chikungunya virus infection. Treatment is generally home remedies such as rest, fluids, and over-the-counter pain and fever medicines aimed at relief of symptoms and signs. The vector. In Asia and the Indian Ocean region, Chikungunya fever is transmitted by the bite of mosquitoes of the genus Aedes which also transmit the dengue virus. Aedes aegypti is considered to be the principal vector and A. albopictus Asian Tiger mosquito has also recently emerged as an important vector. In a nonhuman primate model of CHIKV infection, chloroquine treatment was shown to exacerbate acute fever and delay the cellular immune response, leading to an incomplete viral clearance Roques et al. 2018.