One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Is quinine the same as plaquenil Plaquenil and sunburn Can plaquenil cause weight gain Eye toxicity hydroxychloroquine SD-OCT is capable of detecting characteristic macular changes of HCQ toxicity. These typical macular abnormalities include loss of the parafoveal ellipsoid zone EZ, parafoveal thinning of the outer nuclear layer ONL and inner plexiform layer IPL, the “flying saucer” sign, and peripapillary nerve fiber layer thinning 12 – 14. Aug 29, 2014 Plaquenil, hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory and autoimmune diseases. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil oct of macula Has anyone experienced plaquenil toxicity with damage to eyes?, The Risk of Retinal Toxicity with Plaquenil Chloroquine as antiamoebicHow longbto take plaquenil after alcoholAutofluorescence plaquenilEffects of plaquenil on the eyesHydroxychloroquine ok to stop I have only been taking Hydroxychloroquine for just over a year and have had no problems. I told the rheumatologist that I had early stages macular degeneration but they said it was not a problem. Recently i have had eye problems, my last eye test was January, so I went back to the optician who sent me to eye casualty. Hydroxychloroquine and macular degeneration - NRAS. Plaquenil Side Effects on Your Eyes and Vision. Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy. Called the macula, causes significant, irreversible sight loss. For this reason patients taking hydroxychloroquine who qualify for regular eye health checks on the. NHS will be offered them. Some patients may have to pay for this service privately. Screening for hydroxychloroquine retinopathy. The aim of screening is not to prevent retinopathy Currently, one of the primary functional screening tests recommended for the evaluation of Plaquenil retinal toxicity is 10-2 white stimulus automated visual fields; however, research shows Asian patients benefited from 24-2 or 30-2 visual fields, given that toxicity often manifests changes beyond the macula in these patients. 9 Because spectral-domain optical coherence tomography SD-OCT is readily accessible and able to detect early structural damage prior to clinical funduscopic findings. Recent advances in spectral-domain optical coherence tomography SD-OCT allow for cross-sectional imaging of the retina in vivo to resolutions of 5 to 10 μm. 11 – 16 Adaptive optics AO imaging corrects for ocular aberrations and allows for direct visualization of the photoreceptor mosaic in vivo to resolutions of ≤2 μm. 17 – 20 This report presents the results of SD-OCT and AO imaging on two patients with known hydroxychloroquine retinopathy.