Chloroquine dosing for lupus retina

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    Chloroquine dosing for lupus retina


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Chloroquine CQ is used to prevent and treat malaria and amebiasis, while hydroxychloroquine HCQ, a less toxic metabolite of chloroquine, is used to treat rheumatic diseases such as systemic lupus erythematosus SLE, rheumatoid arthritis RA, juvenile idiopathic arthritis JIA and Sjogren's syndrome. Hydroxychloroquine oral tablet is available as a brand-name drug and a generic drug. Brand name Plaquenil. Hydroxychloroquine comes only as a tablet you take by mouth. Hydroxychloroquine is used to treat malaria, lupus erythematosus, and rheumatoid arthritis. Robert A. Mittra, William F. Mieler, in Retina Fifth Edition, 2013. Chloroquine. Chloroquine was first used as an antimalarial drug in World War II. Currently it is prescribed for treatment of amebiasis, rheumatoid arthritis, and systemic lupus erythematosus in countries primarily outside the United States, and for prophylaxis against malaria.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Chloroquine dosing for lupus retina

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  3. Sep 15, 2014 Specifically, a daily dose of 6.5mg/kg based on ideal body weight and a cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine are both considered risk factors for retinal toxicity. Therefore, lower daily doses do not necessarily preclude patients from developing toxicity due to the risk from cumulative dosage.

    • Retinal Screening for Hydroxychloroquine Plaquenil Toxicity..
    • Chloroquine Retinopathy - an overview ScienceDirect Topics.
    • Spotlight Case Chloroquine - The American Society of Retina..

    No patient was found to have retinopathy. No correlation could be found between indices of visual field function and total drug usage, average daily dose, dosage in mg/kg body weight or duration of treatment. Retinopathy is unlikely to occur at dosages of hydroxychloroquine of less than 6.5 mg/kg body weight with under 10 years of treatment. Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy Retinal toxicity from chloroquine CQ and its analogue, hydroxychloroquine HCQ, has been recognized for many years. Chloroquine toxicity remains a problem in many parts of the world, but is seen less frequently in the United States where the drug largely has been replaced by HCQ. Hydroxychloroquine is generally prescribed at a daily dose of 6.5 milligrams or less per kilogram of body weight. Using this formula, the dosage for a 150-pound person would be 443 mg/day, as one kilogram equals 2.2 pounds. Because HCQ is formulated as a 200 mg tablet, many people taking it for lupus will take two pills per day.

     
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    According to the National Institute on Drug Abuse, the three classes of prescription drugs that are often abused include: Opioids used to treat pain Central nervous system (CNS) depressants, such as benzodiazepines (Xanax, Valium, Ativan, Klonopin), used to treat anxiety and sleep disorders Stimulants, such as amphetamine and dextroamphetamine (Adderall) or methylphenidate (Concerta, Daytrana, Methylin, Ritalin) used to treat attention deficit disorder and narcolepsy (a sleep disorder). Pill Identifier - Find Pills by Color, Shape, Imprint, or Picture Hydroxychloroquine Oral Uses, Side Effects, Interactions. Chloroquine Basics, Side Effects & Reviews -
     
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    Chloroquine inhibits production of TNF-α, IL-1β and IL-6.
     
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