Several drugs that initially were used to prevent or treat malaria are now also used for treating lupus including quinacrine, chloroquine, and hydroxychlorquine. These drugs treat lupus symptoms by mildly suppressing the immune system, which reduces inflammation throughout the body. Methylprednisolone and hydroxychloroquine What does hydroxychloroquine look like A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. The association of the two antimalarials chloroquine and quinacrine for treatment-resitant chronic and subacute cutaneous lupus erythematosus. Dermatology 1994; 189 425-7. Lipsker D, Piette J-C, Cacoub P, et al. Chloroquine-quinacrine association in resistant cutaneous lupus. The antimalarial drugs chloroquine, hydroxychloroquine and quinacrine are reviewed with respect to the history of their use, pharmacokinetics, mode of action DNA interactions, melanin binding, anti-inflammatory, immunosuppressive, sunscreen effects, toxicity cutaneous, haematological, neuromuscular, ocular and usage. Brief guidelines for antimalarial therapy are given. It may be related to an inability to clear damaged cells from the body, which causes excessive stimulation of the immune system. While the exact cause of lupus is not known, it is likely due to a combination of genetic and environmental factors. Quinacrine chloroquine antimalarial Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center, Quinacrine Hydrochloride Drug Information, Professional Can you combine doxycycline hyclate with plaquenilHydroxychloroquine and tinnitusPlaquenil infoIs hydroxychloroquine safe while pregnant Pergamon Press pic Antimalarial activity of optical isomers of quinacrine dihydrochloride against chloroquine-sensitive and -resistant Plasmodium falciparum in vitro Received 22 October 1990; accepted 12 September 1991 While chloroquine has for many years been the mainstay of malaria prophylaxis and treatment, the extensive spread of. Antimalarial activity of optical isomers of quinacrine.. Antimalarial agents. Chloroquine, hydroxychloroquine and.. Chloroquine - Wikipedia. The antimalarial drugs chloroquine, hydroxychloroquine and quinacrine are reviewed with respect to the history of their use, pharmacokinetics, mode of action DNA interactions, melanin binding, anti-inflammatory, immunosuppressive, sunscreen effects, toxicity cutaneous, haematological, neuromuscular, ocular and usage. Patients taking hydroxychloroquine and chloroquine should be monitored by an ophthalmologist to screen for a very rare eye side effect called antimalarial retinopathy. Quinacrine, which does not cause retinopathy, is used commonly in combination with, or in patients who cannot take, hydroxychloroquine or chloroquine. The effects of antimalarial drugs on the intracellular signaling leading to activation of the phospholipase C and phospholipase A 2 pathways and the induction of proinflammatory cytokines have been studied in mouse macrophages. 2. Both chloroquine and quinacrine, and to a lesser extent hydroxychloroquine, inhibited arachidonate release and eicosanoid formation induced by phorbol diester.