It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Hydroxychloroquine tablets ip hcqs-400 Remove chloroquine phosphate Hydroxychloroquine Pregnancy Warnings Animal studies have revealed evidence of fetal harm. Use of chloroquine and other 4-aminoquinolines in high doses and for prolonged durations has been associated with neurological disturbances and interference with hearing, balance, and vision in the fetus. Contraindications. Known hypersensitivity to, or retinal or visual field changes associated with quinoline compounds; psoriasis, porphyria, long-term therapy in children; pregnancy category C. Safe use in juvenile arthritis or lactation is not established. Women with rheumatic diseases, including inflammatory arthritis and systemic lupus erythematosus SLE, fare better in pregnancy when their disease is under good control1,2. The role of hydroxychloroquine HCQ for achieving this control is now recognized. Several studies demonstrate that patients with SLE who continue HCQ during pregnancy have decreased flares and improved pregnancy outcomes. For prolonged treatment of lupus or arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anaemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. For short-term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea and vomiting. Plaquenil pregnancy category c Plaquenil hydroxychloroquine sulfate dosing, indications., HYDROXYCHLOROQUINE SULFATE Chloroquine 250 mgHydroxychloroquine and liver Plaquenil hydroxychloroquine has a good safety record in lupus pregnancy, and is usually continued if needed to control maternal lupus. Management and Monitoring. Lupus pregnancy should be timed to coincide with a period of good disease control if at all possible. Lupus and Pregnancy Johns Hopkins Lupus Center. Too Little of a Good Thing Hydroxychloroquine in Pregnancy.. Too Little of a Good Thing Hydroxychloroquine in Pregnancy. My rheumatologist prescribed me Plaquenil, he’s assured me it’s safe during pregnancy and I plan to contact my OB tomorrow to get her thoughts. I’m just so anxious because I want the pain to go away and enjoy my pregnancy as much as one can but I also don’t want to do anything at all to harm my unborn baby. Hydroxychloroquine is usually considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of using hydroxychloroquine during pregnancy see Plaquenil and Pregnancy for more information. Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.