Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties. Plaquenil vomiting Plaquenil and sunburn Hydroxychloroquine interstitial lung disease Plaquenil medicine Chloroquines are expected to have diverse effects on cancer progression. Inhibition of late autophagy can affect cell survival, as well as antigen processing and presentation in the immune system. Co. Chloroquine as an Anti-autophagic Radiosensitizing Drug in Stage I-III Small Cell Lung Cancer Chloroquine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Apr 14, 2014 Chloroquine diphosphate CQ, an anti-malarial drug, shows potential anti-cancer effects, such as the inhibition of cell growth in human lung cancer A549 cells, human breast cancer cells, and. In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms). Chloroquine for lung cancer Polymeric chloroquine as an inhibitor of cancer cell., Chloroquine as an Anti-autophagic Radiosensitizing Drug in. Plaquenil for hallux limitusChloroquine drug info Chloroquine enhances the cytotoxicity of topotecan by inhibiting autophagy in lung cancer cells Chloroquine enhances the cytotoxicity of topotecan by.. Chloroquine potentiates the anti-cancer effect of lidamycin.. Chloroquine & Hydroxychloroquine supporting chemo.. Cancer is a disease in which cells in the body grow out of control. When cancer starts in the lungs, it is called lung cancer. Lung cancer begins in the lungs and may spread to lymph nodes or other organs in the body, such as the brain. Cancer from other organs also may spread to the lungs. Autophagy and cancer. A large body of evidence suggests that the relationship between autophagy and cancer is complex.42, 43 On the one hand, autophagy appears to inhibit malignant transformation, reflecting its capability to limit the accumulation of potentially oncogenic entities like depolarized mitochondria which overproduce potentially genotoxic reactive oxygen species, ROS. Chloroquine diphosphate CQ, an anti-malarial drug, shows potential anti-cancer effects, such as the inhibition of cell growth in human lung cancer A549 cells, human breast cancer cells, and glioma cells 8,9,10. In addition, CQ therapy enhances the inhibitory effects of other chemotherapeutic agents on tumors.