Plasmodium resistance to chloroquine

Discussion in 'Generic Chloroquine' started by S&S, 17-Mar-2020.

  1. almayarov User

    Plasmodium resistance to chloroquine


    Rapid diagnostic assays for Pf CRT mutations are already employed as surveillance tools for drug resistance. Here, we review recent field studies that support the central role of Pf CRT mutations in chloroquine resistance.

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    Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Whether the protein mediates extrusion of the drug acting as a channel or as a carrier and which is the protonation state of its chloroquine substrate is the subject of a. Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy. The tremendous success of chloroquine and its heavy use through the decades eventually led to chloroquine resistance in Plasmodium falciparum and Plasmodium vivax the 2 parasite species responsible for most human malaria cases.

    Recognition of the value of chloroquine was delayed, and it was not brought forward until it was reevaluated in the United States and designated the drug of choice against malaria near the end of World War II [3]. These studies suggest chloroquine resistance arose in ⩾4 distinct geographic foci and substantiate an important role of immunity in the outcomes of resistant infections after chloroquine treatment. Investigation of the resistance mechanisms and of the role of immunity in therapeutic outcomes will support new approaches to drugs that can take the place of chloroquine or augment its efficiency Early in the 20th century, intense demands for an effective quinine substitute launched the discovery and evaluation of a series of organic compounds (beginning with methylene blue), which led to pamaquine and quinacrine after World War I and ultimately produced chloroquine in 1934 [1, 2].

    Plasmodium resistance to chloroquine

    Drug Resistance in the Malaria-Endemic World, Chloroquine mechanism of drug action and resistance in.

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  7. We evaluated 2 drug resistance markers, the P. falciparum chloroquine resistance transporter pfcrt gene and the artemisinin resistance gene Kelch 13 k13, in malaria parasites in Haiti to determine prevalences and provide information and recommendations for clinical practice to support malaria elimination efforts.

    • No Plasmodium falciparum Chloroquine Resistance Transporter..
    • Chloroquine-Resistant Malaria The Journal of Infectious Diseases..
    • Drug Resistance in the Malaria-Endemic World - CDC.

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. ovale, and P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. The Plasmodium falciparum chloroquine resistance transporter is associated with the ex vivo P. falciparum African parasite response to pyronaridine. Parasit. Vectors 9, 77 2016. Extrusion of chloroquine CQ from digestive vacuoles through the Plasmodium falciparum CQ resistance transporter PfCRT is essen- tial to establish CQ resistance of the malaria parasite.

     
  8. suharr Moderator

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Long-Term Additive Cardiovascular Benefit of Plaquenil and. Abnormal Weight Gain and Gut Microbiota Modifications Are Side Effects. Common Plaquenil side effects - a study from FDA data
     
  9. AnSuperShop Well-Known Member

    Description: An exception occurred while processing your request. What can Hydroxychloroquine Plaquenil do to my eyes? Chloroquine retinopathy - Wikipedia Hydroxychloroquine Plaquenil Toxicity and.
     
  10. MrBinn Moderator

    Plaquenil and Cyclobenzaprine hydrochloride drug. The study is based on hydroxychloroquine sulfate and cyclobenzaprine hydrochloride the active ingredients of Plaquenil and Cyclobenzaprine hydrochloride, respectively, and Plaquenil and Cyclobenzaprine hydrochloride the brand names. Other drugs that have the same active ingredients e.g. generic drugs are not considered.

    Cyclobenzaprine Hydrochloride cyclobenzaprine.
     
  11. posterkun Guest

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