Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine cost 6 tablets Plaquenil inflammatory arthritis Plaquenil drugbank Taking plaquenil and carafate Aug 14, 2013 Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1–5. Retrospective studies cite the incidence of drug-related hyperpigmentation from hydroxychloroquine to be as high as 33% of individuals. Elder abuse is a cause of significant morbidity and mortality in older individuals 7–9. A total of 41 patients 38 women and 3 men were included in the study. The mean age was 39.2 ± 15.4 years. The hydroxychloroquine was indicated for systemic lupus erythematosus in 73.2%, dermatomyositis in 12.2%, rheumatoid arthritis in 9.8%, actinic lichen and sarcoidosis each in 2.4%. Treatment consisted of discontinuing HCQ, which led to the gradual decrease in hyperpigmentation of lesions within several months 5,6. Although there is evidence that both melanin and iron deposits can be present within the dermis in hyperpigmented lesions induced by HCQ 1. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Treatment of plaquenil hyperpigmentation Persistent cutaneous hyperpigmentation due to., Hydroxychloroquine-induced hyperpigmentation in systemic. Chloroquine in lentiviral transductionHydroxychloroquine and nerve damagePlaquenil sex drive Drugs & Medications Plaquenil. Plaquenil Side Effects by Likelihood and Severity INFREQUENT side effects. changing any diet or commencing or discontinuing any course of treatment. Common and Rare Side Effects for Plaquenil Oral. Hydroxychloroquine-induced Hyperpigmentation of the Skin.. Hydroxychloroquine‐induced hyperpigmentation the staining.. Sep 13, 2019 Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Drug-induced skin pigmentation accounts for 10–20% of all cases of acquired hyperpigmentation. Pigmentation may be induced by a wide variety of drugs; the main ones implicated include non-steroidal anti-inflammatory drugs NSAIDs, phenytoin, antimalarials, amiodarone, antipsychotic drugs, cytotoxic drugs, tetracyclines, and heavy metals. Hyperpigmentation is a medical term used to describe darker patches of skin. These patches result from excess melanin production, which can be caused by everything from acne scars and sun damage.