I started on it just less than 2 weeks ago, and I'm surrounded by ill people at work and already have a bit of a cold (nothing severe). it is "milder" than a lot of the other dmards in terms of side effects and activity x It is listed as having a mild immunosuppressant effect in my book on RA, but one of the reasons for the blood tests is to check that your immune system is not being suppressed too much (eg checking your white blood cell levels), so you shouldn't be completely vulnerable. Even after several years of taking lots of drugs I've not found any difference in the number of colds etc I get, and loads of people on here are teachers etc who get a lot of exposure to colds and coughs without too much problem. Plaquenil reduce immune system Can plaquenil cause lung problems Pics of ocular side effects chloroquine Plaquenil homeopathy A recent large study of people with cardiovascular disease found that hydroxychloroquine Plaquenil does not increase the risk of infection and methotrexate increases the risk of infection only slightly. The concern with immune suppression is that the virus could replicate more freely and cause more severe or extensive disease, says Dr. Winthrop. Overall, most serious fungal infections are rare, but they do happen. They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. Hydroxychloroquine Plaquenil is the drug of choice for many physicians who treat rheumatologic skin diseases. It is the most readily available and frequently prescribed antimalarial in the US. Antimalarial medications are extremely safe and do not overtly suppress the immune system. Polly Thank you both, I thought it shouldn't be too bad and that it's pretty mild in comparison to other drugs. Always better to be well informed and I remember the consultant saying its bit a bad time of year to start on it as I've missed all the bugs round Christmas time so thought there may be a slim chance of it being suppressed. But do look after yourself, and make sure you eat well and don't get too tired as if you have a cold already you need to pamper yourself a bit more than you would have before RA. Does plaquenil suppress your immune system Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria, Medications that Weaken Your Immune System and Fungal. Chloroquine treatment freshawaterHydroxychloroquine neuropathyLevaquin reactions with plaquenilWhat type muscle weakness with plaquenil Plaquenil changes the way your immune system works. In some kinds of lupus, your immune system attacks your body instead of protecting it. Plaquenil tries to quiet or slow down the immune system. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Antimalarial Medications RDS. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Howdy LadyDi, sorry you are having problems. Plaquenil is what is call an immune modifier. It is not a immune suppressant. Originally it was used to prevent Malaria. Then it was discovered to be effective for the treatment of Lupus. Plaquenil has the least amount of side affects in treating auto immune disorders. The way I've always understood it, Plaquenil is NOT a immunosupressant. Immunopressant's are meds that suppress the immune system.prednisone.drug suppresses our immune system, calms it down so that our psycho immune system won't turn around and attack us so much. Apr 01, 2013 Methotrexate does suppress the immune system, but serious infections with methotrexate are not common. Your rheumatologist will monitor you closely for any side effects associated with methotrexate such as liver test abnormalities, pneumonitis, or infections. Almost all autoimmune diseases require the immune system be suppressed to some degree.