Saposin b binds chloroquine

Discussion in 'Northwest Pharmacy' started by iunewind, 10-Mar-2020.

  1. aksystems Moderator

    Saposin b binds chloroquine


    Fadi Bou-Abdallah, Britannia Smith, John Paliakkara; (Second row) Nicholas Flint, Kedwin Ventura; (Back row) Lindsay Johnson, Alaa Farghli, Daniel Coelho Beautiful SUNY Potsdam Campus! The drug chloroquine has long been used to treat malaria, but it is not without side effects.

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    The team identified a protein called saposin B in the lysosome of the human cell and showed that it binds chloroquine. By binding chloroquine, saposin B may reverse the undesirable side effects of chloroquine and alleviate its toxicity, potentially by flushing the drug. Structure of saposin B in complex with chloroquine. Note Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Because saposin B binds both lipids and the drug, prolonged use of the drug may keep saposin B busy binding chloroquine instead of removing damaged lipids from the cell, Doyle says.

    While treatments for the disease exist, cures can also take a hefty physical toll. To better understand how chloroquine toxicity occurs, medical researchers set out to investigate what the drug binds to in human cells. According to the Centers for Disease Control and Prevention, over 500,000 individuals died from malaria in 2013 alone.

    Saposin b binds chloroquine

    Saposin B is the dominant saposin that facilitates lipid., RCSB PDB - 4V2O Structure of saposin B in complex with.

  2. 400 mg hydroxychloroquine
  3. Chloroquine and proguanil brand
  4. However, the full extent of CQ pharmacology in humans is still unclear. Herein, we demonstrate that the lysosomal protein saposin B sapB, critical for select lipid degradation, binds CQ with implications for both CQ function and toxicity.

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    About. My previous research experiences focused on Metal-citrate transport in K. radiotolerans, investigating the binding of human Saposin B to antimalarial drugs, the total synthesis of 8,16. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen.

     
  5. diez XenForo Moderator

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. CDC - Malaria - Travelers - Malaria Information and. Guatemala Malaria IAMAT Anti Malaria pills. - Guatemala Forum - Tripadvisor
     
  6. Mooney Guest

    Hydroxychloroquine Oral Route Description and Brand Names. Description and Brand Names. Drug information provided by IBM Micromedex US Brand Name. Plaquenil; Descriptions. Hydroxychloroquine is used to treat malaria. It is also used to prevent malaria infection in areas or regions where it is known that other medicines eg, chloroquine may not work.

    Plaquenil and Bloating. DailyStrength