Fadi Bou-Abdallah, Britannia Smith, John Paliakkara; (Second row) Nicholas Flint, Kedwin Ventura; (Back row) Lindsay Johnson, Alaa Farghli, Daniel Coelho Beautiful SUNY Potsdam Campus! The drug chloroquine has long been used to treat malaria, but it is not without side effects. The avgerage dosage a person takes of plaquenil Hydroxychloroquine pneumococcal vaccine The team identified a protein called saposin B in the lysosome of the human cell and showed that it binds chloroquine. By binding chloroquine, saposin B may reverse the undesirable side effects of chloroquine and alleviate its toxicity, potentially by flushing the drug. Structure of saposin B in complex with chloroquine. Note Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Because saposin B binds both lipids and the drug, prolonged use of the drug may keep saposin B busy binding chloroquine instead of removing damaged lipids from the cell, Doyle says. While treatments for the disease exist, cures can also take a hefty physical toll. To better understand how chloroquine toxicity occurs, medical researchers set out to investigate what the drug binds to in human cells. According to the Centers for Disease Control and Prevention, over 500,000 individuals died from malaria in 2013 alone. Saposin b binds chloroquine Saposin B is the dominant saposin that facilitates lipid., RCSB PDB - 4V2O Structure of saposin B in complex with. 400 mg hydroxychloroquineChloroquine and proguanil brand However, the full extent of CQ pharmacology in humans is still unclear. Herein, we demonstrate that the lysosomal protein saposin B sapB, critical for select lipid degradation, binds CQ with implications for both CQ function and toxicity. The Lysosomal Protein Saposin B Binds Chloroquine - Huta - 2016.. Syracuse University chemists expose side effects of.. The Lysosomal Protein Saposin B Binds Chloroquine - CORE. About. My previous research experiences focused on Metal-citrate transport in K. radiotolerans, investigating the binding of human Saposin B to antimalarial drugs, the total synthesis of 8,16. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen.