Suddenly I'm experiencing eye problems (blilnd spots). I have stopped taking plaquenil, but now I'm being told by doctors that the damage is not necessarily reversible especially if you have taken it for a long time. Side effects of hydroxychloroquine medication Plaquenil and prednisone Critical Warning Signs of Retinal Damage. Have you been dealing with vision problems recently that are worse than normal? If you see any of these symptoms, chances are you have retinal damage and should seek us out for assistance. Hydroxychloroquine has significantly less retinal toxicity and has largely replaced chloroquine as a treatment of inflammatory disease. Unfortunately, the retinal damage from these medications is largely irreversible, so it is critical to detect early retinal toxicity in the hopes of limiting the extent of visual loss. Sign/Symptoms Plaquenil is an extremely safe medication but retinal and corneal side effects are possible. Unfortunately, the retinal side effects are largely irreversible and can lead to vision loss. So, it is critical to detect early retinal toxicity in the hopes of limiting the extent of visual loss. My mother was diagnosed with Plaquenil Toxicity in 2007 she first noticed changes in 2006, although being followed by her eye doctor they failed to notice this as Plaquenil TX until it was to late. I'm hoping to find people who have recovered from the eye damage. Signs of retinal damage from plaquenil Protecting your eyesight when taking Plaquenil Lupus., Hydroxychloroquine Plaquenil Toxicity and Recommendations for Screening Buy plaquenil 200mgTreatment for eye issues after taking plaquenil So I went to the ophthalmologist which was my third opinion and have been continuing to see him for the past 3 1/2 years. I am going blind because of the retinal atrophy due to the plaquenil Normally after you stop plaquenil your eyes will stay at the damage level that was caused to it, but in rare cases the damage will continue. Has anyone experienced plaquenil toxicity with damage to eyes?. Plaquinel Related Eye Problems - Fraser Eye Care Center. Retinal Physician - Hydroxychloroquine Maculopathy An Update.. Plaquenil toxicity is typically asymptomatic in early stages, but over time can lead to severe vision loss and retinal damage. The risk of retinal toxicity was initially believed to be less than 1% after long-term or a cumulative dosage of 1,000mg. 3 The toxicity would double by 10 years, resulting in a 20% prevalence after 20 years. 4. Although it is considered rare, retinal toxicity from the intake of Plaquenil can be irreversible even if the drug is discontinued 2, 3. What is Plaquenil Toxicity? The toxicity resulting from the intake of Plaquenil is due to its affinity for melanin-containing structures in the body. Plaquenil is a drug used to treat Rheumatoid Arthritis and Systemic Lupus Erythematosis. It is a very good drug and gives many patients significant relief from their symptoms. Plaquenil related eye complications are not common. Plaquenil can produce pigment changes in the macula of the retina.