What is chloroquine base

Discussion in 'Plaquenil 200mg' started by anandasat, 28-Feb-2020.

  1. xtrim Well-Known Member

    What is chloroquine base


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    Initial dose, use 1 gram of chloroquine phosphate 600 mg base taken 1 time / week on the same day each week Maintenance dose 500 mg of chloroquine phosphate 300 mg base taken after 6-8 hours, then 500 mg of chloroquine phosphate 300 mg base taken 1 time / day for 2 consecutive days. Doses expressed as chloroquine base. Each tablet contains 155 mg of chloroquine base equivalent to 250 mg of chloroquine phosphate. Syrup contains 50 mg/5 mL of chloroquine base equivalent to 80 mg/5 mL of chloroquine phosphate. I am trying to figure out where the drug chloroquine comes from? Is it plant based, or completely, chemically engineered? If you can find any resources, I would appreciate it a lot. I have not found any online, and I have been searching for a while. Thanks!

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    What is chloroquine base

    CHLOROQUINE PHOSPHATE, USP, CHLOROQUINE Drug BNF content published by NICE

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  5. Best Answer Quinine is a natural product extracted from the bark of the cinchona tree. It was discovered to be a prophylactic against malaria. The Brits in India used it in combination with lemon juice, sugar and soda water to make tonic water, which helps reduce your chances of catching malaria there.

    • What is the plant base of the anti-malaria drug chloroquine?.
    • What is the plant base of the anti-malaria drug chloroquine..
    • Chloroquine Oral Uses, Side Effects, Interactions..

    Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. The dosage of Chloroquine phosphate is often expressed in terms of equivalent Chloroquine base. Each 500 mg tablet of Chloroquine phosphate contains the equivalent of 300 mg Chloroquine base. In infants and children the dosage is preferably calculated by body weight. Prophylaxis against Chloroquine-sensitive Plasmodium species Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion.

     
  6. Lancelot Moderator

    Selected from data included with permission and copyrighted by First Databank, Inc. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic HYDROXYCHLOROQUINE - ORAL Plaquenil side effects, medical. Common and Rare Side Effects for Plaquenil Oral
     
  7. Zambrotta New Member

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Having issues with Plaquenil - Hydroxychloroquine - Side Effects, Dosage, Interactions. Gastroesophageal reflux disease in Plaquenil how severe and.
     
  8. Den2006 Well-Known Member

    ICD-10-CM Diagnosis Code Z79.899 Other long term. Free, official coding info for 2020 ICD-10-CM Z79.899 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.

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