Is chloroquine safe during pregnancy

Discussion in 'Trust Pharmacy Canada' started by Sonja, 13-Mar-2020.

  1. independent New Member

    Is chloroquine safe during pregnancy


    While the mechanism is poorly understood, pregnant women have a reduced immune response and therefore less effectively clear malaria infections. In addition, malaria parasites sequester and replicate in the placenta.

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    As these have proved safe and efficacious in pregnancy 5. Hydroxychloroquine in particular is associated with improved obstetric outcomes in SLE 9. Chloroquine, although grouped with hydroxychloroquine in table 2 of this article, is not routinely used in the management of SLE either in or out of pregnancy due to increased tissue Anti-malarial drugs hydroxychloroquine, chloroquine are considered pregnancy category C drugs. While there is evidence of risk for damage to the eye and ear, if the benefits of these drugs in controlling RA symptoms are judged to outweigh the risks, they may continue to be used during pregnancy. 1,2 Pregnancy and Chloroquine According to the Centers for Disease Control and Prevention CDC, chloroquine is considered safe to use during pregnancy. Tell your doctor if you're pregnant or might.

    Malaria infection during pregnancy can lead to miscarriage, premature delivery, low birth weight, congenital infection, and/or perinatal death. Pregnant women are three times more likely to develop severe disease than non-pregnant women acquiring infections from the same area.

    Is chloroquine safe during pregnancy

    Chloroquine - Wikipedia, Drug Safety in Pregnant & Nursing Women.

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  7. CONCLUSION Our findings support preliminary evidence for the safety of HCQ therapy during pregnancy. This treatment probably should be maintained throughout pregnancy in patients with systemic lupus erythematosus.

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    • Chloroquine Aralen - Side Effects, Dosage, Interactions..
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    Summary. Aralen is the brand name for the generic drug chloroquine, an anti-malaria drug used to treat malaria and amebiasis infection that's spread outside of the intestines. Dosage, drug interactions, and pregnancy and breastfeeding safety information should be reviewed prior to taking this drug. A body of clinical experience suggests chloroquine is safe during pregnancy and improves outcome in women with active disease. In one study of 96 women with active malaria, chloroquine 10 mg/kg was given at time 0 and 24 h and again at 48 h 5 mg/kg. Chloroquine is the drug of choice for the prophylaxis and treatment of sensitive malaria species during pregnancy. Chloroquine should only be given during pregnancy when need has been clearly established. See references. Chloroquine Breastfeeding Warnings. Chloroquine is excreted into human milk.

     
  8. seomaxi New Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Compare Plaquenil vs Chloroquine - Chloroquine Oral Uses, Side Effects, Interactions, Pictures. What is Chloroquine Phosphate? - GoodRx
     
  9. Montano New Member

    Chloroquine inhibits autophagic flux by decreasing. Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. We show that CQ mainly inhibits autophagy by impairing autophagosome fusion with lysosomes rather than by affecting the acidity and/or degradative activity of this organelle. Furthermore, CQ induces an autophagy-independent severe disorganization of the Golgi.

    Chloroquine Dosage Guide with Precautions -