One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Regulate nk cells inflammation plaquenil Hydroxychloroquine wr Map of malaria regions chloroquine resistance The AAO published dosing and screening recommendations for chloroquine and hydroxychloroquine in 2016, revising previous recommendations published in 2011. The current maximum daily HCQ dose recommended by the AAO is 5 mg/kg of real weight. The 2011 guidelines suggested a maximum dose of 6.5 mg/kg of ideal weight. Dosing. Hydroxychloroquine is generally prescribed at a daily dose of 6.5 milligrams or less per kilogram of body weight. Using this formula, the dosage for a 150-pound person would be 443 mg/day, as one kilogram equals 2.2 pounds. Because HCQ is formulated as a 200 mg tablet, many people taking it for lupus will take two pills per day. Twenty-seven percent of cases of hydroxychloroquine retinopathy in obese women had ostensibly safe dosing based on 2016 AAO guidelines. Overdosing of obese women by 2016 AAO guidelines is not rare. Daily dosing based on the older 6.5-mg/kg ideal weight threshold is safer in women with a body mass index of 30 kg/m 2 or more. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Aao plaquenil dosing My Take on New Ocular Screening Guidelines for Plaquenil., Drug spotlight on hydroxychloroquine Lupus Foundation of. Plaquenil medication oral pigmentationWill plaquenil cause weight gainPlaquenil mouth side effectsRash dissappears with plaquenil a month Braslow et al. examined rheumatologists’ adherence to the hydroxychloroquine HCQ dosing guidelines published by the American Academy of Ophthalmology in 2011 and revised in 2016. They performed a review of records at a single integrated health care entity NorthShore, Glenview, Ill. and found that about half of the patients on HCQ were prescribed higher doses than those recommended in the guidelines. Adherence to Hydroxychloroquine Dosing Guidelines by.. The 2016 American Academy of Ophthalmology Hydroxychloroquine.. Plaquenil hydroxychloroquine sulfate dose, indications.. Abstract Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Doses ≥ 5 mg/kg/day real weight of hydroxychloroquine 2.3 mg/kg/day of chloroquine are associated with higher risk of toxicity. Doses lower than 5 mg/kg/day have low risk 1% for the first 5 years, and below 2% between 5-10 years of use. The longer you use the medication, the higher the risk of toxicity. Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.