Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Apo hydroxychloroquine side effects Is hydroxychloroquine an immunosuppressant drug Hydroxychloroquine 200 mg overdose Both leflunomide and hydroxychloroquine have been shown to inhibit B-cell hyperactivity, but the clinical benefits have been modest and not statistically significant. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. MONDAY, Nov. 26, 2007 HealthDay News -- Combining an older synthetic drug with a newer, "biologic" medication may work best to ease the joint swelling and tenderness of rheumatoid arthritis, a new study finds. Hydroxychloroquine may also be used for purposes not listed in this medication guide. Hydroxychloroquine is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine and leflunomide together Hydroxychloroquine oral Plaquenil Oral. - RxList, Hydroxychloroquine Plaquenil Ocular toxicity of hydroxychloroquinePlaquenil and chest pain Early, aggressive disease management is critical for halting disease progression and joint destruction in patients with rheumatoid arthritis. Combination therapy with at least two disease-modifying antirheumatic drugs, such as methotrexate MTX, sulfasalazine, or hydroxychloroquine, is often more effective than monotherapy in reducing disease activity. Combination Therapy for Rheumatoid Arthritis in the Era of Biologicals. Drug Combos Effective Against Rheumatoid Arthritis. Hydroxychloroquine - Side Effects, Dosage, Interactions.. Patients received treatment with leflunomide and methotrexate and 133 subjects were randomized to placebo and methotrexate. The response rate of ACR20 criteria P0.001 at week 24 was 46.2% and 19.5% for the leflunomide and placebo groups respectively. Conventional DMARDs that have been paired with methotrexate include sulfasalazine, hydroxychloroquine, cyclosporine, leflunomide and azathioprine. Although studies of these combinations have shown differing levels of benefit, the combinations of methotrexate plus leflunomide and methotrexate plus sulfasalazine are among the most effective. Leflunomide, a disease-modifying anti-rheumatic drug DMARD that inhibits DNA synthesis, is a common alternative to MTX. Whether leflunomide can be used as an alternative for MTX in combination with SSZ and HCQ has not previously been studied.